The development of national experimental teaching demonstration center plays an important role in the development of national higher education and the cultivation of innovative talents. To investigate the research and development of national demonstration center for experimental education, this paper selects journal articles from 2005 to 2022 in the CNKI database with the theme of "national demonstration center for experimental education" as the research object. Using visual analysis software such as VOSviewer and CiteSpace, the paper analyzes the characteristics, development context, hot spots, and frontier trends of the literature. The results show that the development of the experimental teaching center has experienced three periods: set-up period, rapid development period and stable development period. Four main research topics have been formed: the experience summary and analysis of the construction of the experimental teaching center, the discussion of experimental teaching mode and teaching effect, the research of management mechanism and operation mode, and the cultivation of college talents based on innovation ability and practical ability. From the perspective of the development trend, the research object is gradually shifting from the traditional laboratory to the virtual simulation laboratory, and the special attention is paid to the construction and development of the experimental teaching demonstration center under the background of new engineering. Through the analysis of the research and development context and hot pots of the national experimental teaching demonstration center, the high-quality development of higher education experimental teaching and the independent cultivation of innovative talents are promoted.