In order to improve the mechanical property of laser deposition TA15 titanium alloy, the harmonic response analysis of the ANSYS finite element dynamic analysis was adopted, amplitude distribution and particle vibration of the bottom surface of the trapezoidal groove surface with ultrasound were simulated, and the experiments were carried out to verify the simulation results. The comprehensive mechanics performance of laser deposition layers with ultrasound was researched by experiment test. The results show that, the points of the bottom surface of the trapezoidal groove with ultrasound presents periodic motion characteristics, and the maximum amplitude is about 1.6 μm, which is in a good agreement with simulation results. The laser deposition experiment with ultrasound was carried out, and the results show that the hardness of deposition repair region increases, tensile strength of deposition repair region rises by 3.2%, yield strength improves by 7.1%, and microstructures with ultrasonic field are observed that the α lamellas become shorter.