Radiation monitoring is crucial to ensure safe, stable, and reliable operation of nuclear technology utilization equipment. The radiation levels at workplaces, in water storage wells, and due to individuals' occupational exposure during the operation of ⁶⁰Co irradiation equipment over the past five years at the Hunan irradiation center have been monitored and analyzed. The results reveal that the radiation levels received by personnel and at various sites are remarkably lower than the national limits. All the source water quality indexes meet the requirements, and the radioactivity does not exceed the standard limits. The grey GM(1,1) prediction model was introduced to perform the prediction analysis based on 5 years of historical radiation monitoring data. The results show negligible change in the radiation level over the next 3 years, and it is considerably below the prescribed limit; hence, no radiation harm to the surrounding environment and human health would be observed.