A 220 GHz tripler frequency multiplier using no-substrate and space combined structure was designed and realized based on four anodes in parallel-series GaAs planar Schottky diodes. Four Schottky diodes was adopted and divided into two groups. One group with two Schottky diodes placed in the same direction was flip-chiped on the top surface of the slab waveguide metal film and the other group on the bottom surface composed anti-series structure. The efficiency of the circuit was stimulated combined of EM simulator and circuit simulator. The stimulated efficiency was bigger than 3% over the band of 213 GHz to 229 GHz with the input power of 300 mW. An E-band power amplifier was used to drive the circuit to get the output power of the multiplier. The measured output power was bigger than 5 dBm over the band of 213 GHz to 229 GHz with the input power of 300 mW. The efficiency was 1% to 2%.