Determination of Thallium in Blood of Occupational Exposed Population by Inductively Coupled Plasma Mass Spectrometry With High Matrix Introduction

Fei ZHANG; Xia HUA; Jia-ying YUAN; Fan YOU; Ren-cai YE; Li DING; Jian-mei ZHAO

doi:10.3964/j.issn.1000-0593(2022)09-2870-05

Journals >Spectroscopy and Spectral Analysis >Volume 42 >Issue 9 >Page 2870 > Article

Spectroscopy and Spectral Analysis
Vol. 42, Issue 9, 2870 (2022)

Determination of Thallium in Blood of Occupational Exposed Population by Inductively Coupled Plasma Mass Spectrometry With High Matrix Introduction

Fei ZHANG^{1,1; 5;}, Xia HUA^{2,2; *;}, Jia-ying YUAN^3,3;, Fan YOU^1,1;..., Ren-cai YE^4,4;, Li DING^4,4; and Jian-mei ZHAO^4,4;|Show fewer author(s)

Author Affiliations

¹1. Sichuan Center for Disease Control and Prevention, Chengdu 610041, China

²2. Sichuan Center for Food and Drug Evaluation, Inspection & Monitoring, Chengdu 610017, China;

³3. Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China

⁴4. Liangshan Zhou Center for Disease Control and Prevention, Liangshan 615000, China

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DOI: 10.3964/j.issn.1000-0593(2022)09-2870-05 Cite this Article

Fei ZHANG, Xia HUA, Jia-ying YUAN, Fan YOU, Ren-cai YE, Li DING, Jian-mei ZHAO. Determination of Thallium in Blood of Occupational Exposed Population by Inductively Coupled Plasma Mass Spectrometry With High Matrix Introduction[J]. Spectroscopy and Spectral Analysis, 2022, 42(9): 2870 Copy Citation Text

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Fig. 1. Mass spectrogram of standard series and internal standard (a); Standard curve equation of thallium (b)

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Fig. 2. Variation of internal standard element signals

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参数	设定值
RF power	1 550 W
Cool gas flow	15.0 L·min^-1
Auxiliary gas flow	0.90 L·min^-1
Plasma gas flow	15 L·min^-1
Nebulizer pump speed	0.1 r·min^-1
Carrier gas flow rate	1.05 L·min^-1
Acquisition mode	Mass spectrogram
Tuning mode	No Gas
Plasma mode	HMI

Table 1. Instrumental parameters for HMI-ICP-MS

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冻干全血质量控制样品	方法	测定值/(μg·L^-1)	精密度/%	误差/%	参考值范围/(μg·L^-1)
	1	11.7, 10.9, 11.0, 11.4, 11.0, 12.8	6.28	11.9
	2	11.0, 10.5, 11.5, 10.2, 10.7, 9.75	5.77	4.79
L-2	3	10.6, 10.8, 10.2, 9.91, 10.7, 10.6	3.26	3.52	10.1(8.1~12.1)
	4	11.2, 11.2, 11.9, 10.9, 11.6, 10.8	3.71	10.4
	5	10.3, 11.1, 11.3, 11.1, 10.7, 10.2	4.25	6.34
	1	32.7, 31.5, 34.4, 33.8, 30.9, 34.2	4.45	3.39
	2	34.4, 33.9, 31.1, 33.8, 34.7, 32.6	4.02	4.84
L-3	3	33.4, 31.9, 33.8, 31.8, 32.4, 32.5	2.47	2.55	31.8(29.0~34.5)
	4	33.8, 32.9, 34.3, 34.5, 31.3, 32.2	3.80	4.12
	5	33.5, 34.5, 32.1, 33.1, 34.2, 33.2	2.56	4.89

Table 2. Analytical results of thallium in blood under different treatments by HMI-ICP-MS (n=6)

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本底 /(μg·L^-1)	加标 /(μg·L^-1)	测得值/(μg·L^-1)	回收率 /%	批内精密度 /%	批间精密度 /%
<0.42	2.50	2.63, 2.70, 2.60, 2.59, 2.55, 2.61, 2.49	103.8	2.52	-
<0.42	2.50	2.71, 2.45, 2.61, 2.44, 2.57, 2.38, 2.64	101.7	-	4.77
<0.42	15.0	15.2, 15.7, 16.3, 15.3, 15.2, 15.6, 16.1	104.2	2.81	-
<0.42	15.0	15.4, 14.0, 14.2, 15.4, 14.9, 15.1, 13.9	92.7	-	4.44
<0.42	75.0	75.6, 74.8, 73.7, 72.9, 75.2, 72.1, 74.3	98.8	1.71	-
<0.42	75.0	75.4, 76.5, 77.3, 72.9, 71.2, 74.6, 73.6	99.3	-	2.84

Table 3. Recovery and precision of the method (n=7)

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