On the basis of the theory of integral time calculation, the error sources of measuring algorithm and residual error were analyzed, and the quantitative analysis and research on the influence of residual error on imaging quality was carried out, the effectiveness of using Harris angle point algorithm to realize sub-pixel location of interframe image motion $ \Delta {{L}}$ was verified by using 50 groups of sample data through MATLAB. The strategy combining the corner threshold optimization and the prior knowledge elimination of mismatching can effectively reduce the amount of operational data, and carry out the sub-pixel location calculation for the matched angle points. The simulation results show that the calculation accuracy of $ \Delta {{L}}$ is better than 0.2 pixel, which can meet the demand of on-orbit use of the calculation method. Finally, with the application characteristics of the real-time calculation method, the imaging parameters of TDI detector high resolution remote sensing camera were proposed, which provided design reference for on-orbit use of the calculation method. Using high frequency plane array CMOS cameras to calculate integral time method can effectively solve the target elevation data is unknown cases, photography slant distance cannot be accurately obtained. Calculation method with low cost and feasibility on orbit, can compensate for the image quality degradation caused by image motion mismatch, which is beneficial to the improvement of imaging performance of TDI detector high resolution remote sensing camera.