Ripple suppression of high voltage DC power supply is always a key issue in laser power technology. For the ripple suppression problem of high voltage DC power supply for high power lasers, full wave voltage doubler rectifier circuit is used to suppress the ripple of power supply voltage, and the voltage series and capacitor capacity in rectifier circuit are optimized by using neural network. According to the optimized parameters, the ripple suppression experiments are carried out in the actual high voltage power supply. Results show that the designed rectifier circuit can significantly enhance the ripple suppression effect.