In view of larger holes and higher density operators with the traditional blasting of packed explosives, this paper launched 60 on-site blasting experiments in a plateau tunnel. The charging efficiency of different numbers of exploders was summarized, the hole network parameters were optimized and smooth blasting effect of peripheral holes were improved. Compared with the smooth blasting effect, the number of holes dropped from 151 to 124. The spacing of peripheral holes was gradually optimized from 45 cm to 60 cm based on the advantages of good mechanical and coupling charging on-site mixed explosives. The result shows that the on-site mixed loading blasting in plateau tunnel can improve more than 40% efficiency per operator and reduce 90% of labor intensity compared with the traditional blasting of packed explosives. It can significantly reduce the number of operators and improve the efficiency of drilling and loading, saving more than 15% of drilling quantity and explosive equipment. Lastly, more than 3% of the utilization of circular footage has been improved, which shows that on-site mixed-loading blasting can accelerate construction progress.