With the discovery of quantum well intermixing (QWI), it has made tremendous progress over the past few years. Among all the approaches of QWI, meticulous researches and wide range of applications are acquired in impurity free vacancy disordering (IFVD) owing to its unique merits. Present status of IFVD research and application is comprehensively analyzed from the aspect of theory, dielectric films, materials, quantum dots and applications.