Optical frequency combs play a crucial role in optical communications, time-frequency metrology, precise ranging, and sensing. Among various generation schemes, resonant electro-optic combs are particularly attractive for their excellent stability, flexibility, and broad bandwidths. In this approach, an optical pump undergoes multiple electro-optic modulation processes in a high-$Q$ optical resonator, resulting in cascaded spectral sidebands. However, most resonant electro-optic combs to date make use of lumped-capacitor electrodes with relatively inefficient utilization of the input electrical power. This design also reflects most electrical power back to the driving circuits and necessitates costly radio-frequency (RF) isolators in between, presenting substantial challenges in practical applications. To address these issues, we present an RF circuit friendly electro-optic frequency comb generator incorporated with on-chip coplanar microwave resonator electrodes, based on a thin-film lithium niobate platform. Our design achieves more than three times electrical power reduction with minimal reflection at the designed comb repetition rate of $\sim 25\mathrm{GHz}$. We experimentally demonstrate broadband electro-optic frequency comb generation with a comb span of $>85\mathrm{nm}$ at a moderate electrical driving power of 740 mW (28.7 dBm). Our power-efficient and isolator-free electro-optic comb source could offer a compact, low-cost, and simple-to-design solution for applications in spectroscopy, high-precise metrology, and optical communications.