Antimony telluride (Sb2Te3) is a new type of two-dimensional layered material, in this paper, the "top-down" ultrasonic exfoliation method was used to prepare antimony telluride quantum dots (Sb2Te3 QDs) for the first time, with antimony telluride powder as raw material, and N-methyl pyrrolidone (NMP) as the dispersant. A variety of characterizations(SEM, TEM, AFM, XPS, XRD, etc.) for the structure and morphology of the prepared Sb2Te3 QDs were performed. The optical properties of Sb2Te3 QDs were studied using UV-Vis, PL and PLE. It is found that the average particle size of the prepared Sb2Te3 QDs is 2.3 nm, and the average height is 1.9 nm, with a good dispersive particle size uniformity, the PL and PLE peaks have a redshift, both PL and PLE are dependent on the excitation wavelength and emission wavelength. It is also found that Sb2Te3 QDs has obvious absorption and photoluminescence in the infrared band. The results indicate that the ultrasonic exfoliation method is feasible to prepare Sb2Te3 QDs, the characteristics of the material show the potential application in infrared detector.