This Letter proposes a high-security modulation scheme for optical transmission systems. By using multi-constellation shaping and asymmetric encryption, the information security can be enhanced and quantum computer cracking can be effectively resisted. Three-dimensional (3D) carrier-less amplitude phase modulation is utilized to superposition and transmit 3D signals. Experimental verification is conducted using a seven-core weakly coupled fiber platform. The results demonstrate that the proposed scheme can effectively protect the system from any illegal attacker.