• Advanced Fiber Materials
  • Vol. 6, Issue 3, 00395 (2024)
Xiaojiao Liu1、†, Xiang Yao1、†, Qinjun OuYang1, Ana L. Oliveira3, Li Yan2、*, and Yaopeng Zhang1、**
Author Affiliations
  • 1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, People’s Republic of China
  • 2The Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China
  • 3Centro de Biotecnologia e Química Fina (CBQF), Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, 4169-005 Porto, Portugal
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    DOI: 10.1007/s42765-024-00395-8 Cite this Article
    Xiaojiao Liu, Xiang Yao, Qinjun OuYang, Ana L. Oliveira, Li Yan, Yaopeng Zhang. Nanofiber Scaffold-Based Tissue Engineering for the Treatment of Acute Liver Failure[J]. Advanced Fiber Materials, 2024, 6(3): 00395 Copy Citation Text show less

    Abstract

    Acute liver failure (ALF) has a mortality rate of more than 40%. Currently, orthotopic liver transplantation is the sole clinical treatment for ALF, but its wide usage is severely limited due to donor shortage and immunological rejection. An emerging and promising technology for ALF treatment is liver tissue engineering (LTE), wherein porous scaffolds serve as a crucial component. Nanofiber scaffolds, which mimic the inherent structures of fibrous extracellular matrix well, provide an ideal environment for cell growth and tissue regeneration. Recently, several functional nanofiber scaffolds for LTE have been developed, which show impressive results in regulating cell function and repairing liver injury when combined with appropriate seeding cells and/or growth factors. This review firstly introduces the etiologies and treatment indicators of ALF. Subsequently, typical fabrication technologies of nanofiber scaffolds and their related applications for function regulation of liver-related cells and treatment of ALF are comprehensively summarized. Particular emphasis is placed on the strategies involving an appropriate combination of suitable seeding cells and growth factors. Finally, the current challenges and the future research and development prospects of nanofiber scaffold-based LTE are discussed. This review will serve as a valuable reference for designing and modifying novel nanofiber scaffolds, further promoting their potential application in LTE and other biomedical fields.
    Xiaojiao Liu, Xiang Yao, Qinjun OuYang, Ana L. Oliveira, Li Yan, Yaopeng Zhang. Nanofiber Scaffold-Based Tissue Engineering for the Treatment of Acute Liver Failure[J]. Advanced Fiber Materials, 2024, 6(3): 00395
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