Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts

Yonghao WU; Xiangfeng LI; Xiangdong ZHU; Xingdong ZHANG

doi:10.15541/jim20200395

Journals >Journal of Inorganic Materials >Volume 36 >Issue 5 >Page 552 > Article

Journal of Inorganic Materials
Vol. 36, Issue 5, 552 (2021)

Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts

Yonghao WU, Xiangfeng LI, Xiangdong ZHU^*, and Xingdong ZHANG

Author Affiliations

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

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DOI: 10.15541/jim20200395 Cite this Article

Yonghao WU, Xiangfeng LI, Xiangdong ZHU, Xingdong ZHANG. Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts[J]. Journal of Inorganic Materials, 2021, 36(5): 552 Copy Citation Text

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1. (A-C) SEM images and (D) particle size distributions of various HA precursor powders

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2. (A) XRD patterns and (B) FT-IR spectra of HA initial powder (HA-40, HA-40PEG, HA-80)

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3. (A) SEM images, (B) average grain sizes and (C) XRD patterns of the three kinds of HA ceramics (HA-40, HA-40PEG and HA-80)

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4. (A) AFM topographies, (B) line profiles, (C) contact angles of the three kinds of HA ceramics (HA-40, HA-40PEG and HA-80)

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5. (A) Relative densities, (B) strain-stress curves, (C) compressive strengths and (D) elastic modulus of the three kinds of HA ceramics (HA-40, HA-40PEG and HA-80)Values are expressed as the mean ± SD (n = 3); *p< 0.05 and **p< 0.01

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6. (A) SEM images, (B) CLSM observations of cytoskeleton, (C) cell area, and (D) CCK-8 results of MC3T3-E1 cultured on HA ceramicsValues are expressed as the mean ± SD (n=3); *p<0.05 and **p<0.01

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Sample	Particle size, D₅₀/nm	Crystallinity, X_c/%	Specific surface area/(m²·g^-1)	Crystallinity index	Maturity index
HA-40	(124.62±28.71)	31.76	(89.76±3.96)	5.91	2.02
HA-40PEG	(65.16±31.23)	39.48	(81.40±0.66)	5.31	1.91
HA-80	(221.50±48.82)	77.94	(41.76±0.71)	7.45	1.86

Table 1.

Physicochemical properties of the three HA precursor powders

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Sample	Crystallinity, X_c/%	Surface roughness, R_a/nm	Contact angle/(°)	Grain size/nm	Relative density/%
HA-40	97.48	(61.49±5.65)	(69.20±6.94)	(217.87±57.53)	(94.90±2.27)
HA-40PEG	96.92	(66.70±2.81)	(56.07±0.42)	(123.22±20.16)	(93.45±3.32)
HA-80	98.33	(57.81±3.44)	(79.83±1.99)	(316.65±68.91)	(85.57±0.91)